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Population dynamics of roundjaw bonefish Albula glossodonta at a remote coralline Atoll inform community-based management in an artisanal fishery. Fisheries Management and Ecology Length-based assessment of an artisanal Albulid fishery in the South Pacific: A data-limited approach for management and conservation. Marine and Coastal Fisheries Litt, M.

Karl schlaepfer erectile dysfunction

Karl schlaepfer erectile dysfunction

Karl schlaepfer erectile dysfunction

Sex differences in corpus callosum size: relationship to age and intracranial size. Loose busty cum Gain Reduction Method for manual tracking of radio-tagged fish in streams. All statistical data were analyzed in SPSS Friedhoff and Raul R. Gallagher, and S. Trites, G. Lydersen, T. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Robertson and S. Vermaire, D.

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To date, there is no consensus whether sexual dimorphism in the size of neuroanatomical structures exists, or if such differences are caused by choice of intracranial volume ICV correction method.

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Disturbed sleep is known to substantially aggravate both the pain condition and the affective state of pain patients. The neurobiological mechanisms underlying these adverse effects are unknown. Oxytocin OT , being largely involved in social and emotional behavior, is considered to also play a modulatory role in nociception.

We hypothesized a pathophysiological role of OT for the hyperalgesic and anxiogenic effects of sleep loss. An established human model of one night of total sleep deprivation TSD was used to test this hypothesis. Plasma OT concentrations were correlated with 1 pain thresholds, 2 descending pain inhibition, and 3 state-anxiety scores. Altogether, our study revealed a complex and partially sex-dependent correlation between plasma OT and TSD-induced changes of experimental pain and anxiety.

The minor role of OT for TSD-induced changes of evoked pain, and its major involvement in anxiety, argues against a specific role of OT for linking the adverse effects of TSD on pain sensitivity and anxiety with each other. Future investigations are needed in order to dissect out the effect of OC on the sex-dependent effects of TSD observed in our study. Disturbed sleep belongs to the major complaints of pain patients Taylor et al.

Clinical and experimental studies have shown that sleep deprivation is able to substantially aggravate the pain condition of pain patients Kundermann et al.

Even more, sleep disturbances and pain are considered to be mutually reinforcing, thus leading to a vicious cycle Benca et al. Though being clinically highly relevant, the neurobiological mechanisms underlying the pro-nociceptive effects of disturbed sleep are barely known.

Beyond its impact on pain, disturbed sleep is also known to deteriorate the affective state of pain patients. Namely, the anxiogenic effect of disturbed sleep is well acknowledged Sagaspe et al. Only recently, the anxiogenic effect of sleep deprivation has been shown to be correlated with brain morphology changes in the ventromedial prefrontal cortex and — in women — with reduced gray matter volume in the anterior insula and lateral orbitofrontal cortex Goldstein-Piekarski et al.

Part of these cortical areas — like the insula and the ventromedial prefrontal cortex — do not only belong to the affective-motivational dimension of pain processing Peyron et al. This neuropeptide, being largely recognized for its role in social behavior Neumann, ; Macdonald and Macdonald, ; Striepens et al.

Several kinds of mechanisms have been described by which OT may contribute to the modulation of nociceptive processing. Supraspinally, extrahypothalamic projections of OT neurons to limbic brain regions, like the anterior cingulate cortex and amygdala, suggest a role of OT for the affective dimension of pain processing Knobloch et al.

At the brainstem level, anatomical Campbell et al. Via hypothalamo-spinal projections to dorsal horn neurons, OT is involved in nociceptive processing at the spinal cord level Schoenen et al. Only recently, a peripheral mode of action was proposed according to which OT may interact with nociceptive-specific nerve terminals in the skin Gonzalez-Hernandez et al.

During the last decade, the anti-nociceptive potency of OT has been intensively studied. Surprisingly, while preclinical evidence strongly points to a considerable role of OT in pain-related behavior, results from human studies are highly equivocal.

Like recently summarized, only about half of the previous human studies on the involvement of OT in nociception were able to confirm anti-nociceptive effects of OT, while the remaining studies failed to convincingly demonstrate a pain modulating role. Differences between methodological approaches to explore the role of OT exogenous application versus assessment of endogenous levels and between outcome measures spontaneous pain versus evoked pain may particularly contribute to the large heterogeneity of study results [see Rash et al.

Compared to the field of pain research, little is known about the contribution of the OT-system for the physiology and pathophysiology of sleep. Only chronobiological aspects have been addressed, indicating that the OT-system is not subject to circadian variations Amico et al. We aimed to explore the neurobiological correlates underlying sleep deprivation induced changes of pain sensitivity and state anxiety.

Backed by current knowledge, we hypothesized a pathophysiological role of OT for both the deterioration of pain and the affective state of sleep deprived individuals. To address this topic, a well-established human experimental model of one-night total sleep deprivation TSD was used. This model has been shown to increase the sensitivity to noxious stimuli Kundermann et al. We hypothesized 1 a significant impact of sleep deprivation on the activity of the OT-system and, hence, on OT-release into the blood circulation and 2 a significant correlation between the concentration of plasma OT and TSD-induced alterations of evoked pain and anxiety.

Since the involvement of OT in social and anxiety-related behavior is highly gender-specific Macdonald, ; Dumais et al. Finally, the salivary concentration of cortisol as a flanking biomarker for the stress-level of our study subjects was determined. This study was carried out in accordance with the Declaration of Helsinki and in accordance with the recommendations of the Local Ethical Committee of the Medical Faculty of Mannheim.

All subjects gave written informed consent prior to study enrollment in accordance with the Declaration of Helsinki. Somatic or psychiatric diseases and, in particular, pain disorders or insomnia were excluded in all study participants by taking their medical history, performing a physical and neurological examination and by using psychological questionnaires BDI Beck et al. Both BDI-scores females: 0.

Primary pain or headache disorders were excluded as well as any serious pain-associated physical trauma. Importantly, females complaining of a peri-menstrual syndrome were excluded from the study. According to our results PSQI: females: 1. Demographic data are shown in Table 1. None of the study participants took analgesics. All study participants were non-smokers. They were asked to abstain from caffeine or any caffeinated beverages at least three days before the experiment took place.

Since estrogens are known to impact on OT synthesis and release Patisaul et al. This condition was fulfilled by the fact that all female study participants were on monophasic contraceptives.

In nine of ten females, the concentration of ethinylestradiol was 0. In seven of the ten female subjects, the experiments were performed at exactly the same day of their menstrual cycle. All study subjects filled in sleep diaries at least five days before experiments took place.

The time-interval between the two study experiments was adjusted to the female cycle. To avoid biasing due to alternation of the sleep-wake rhythm from weekend to weekday, experiments never took place on Mondays. For double-check, participants had to keep wearing the Actiwatch device also during the sleep deprivation night. Analysis of Actiwatch data revealed an average total sleep time on weekdays of 7.

After a drug screening test Drug-Screen, nal von minden GmbH, Germany and before serving breakfast, saliva cortisol and blood samples OT were collected. All participants ate a standard breakfast white bread, butter, honey, fruit, or herbal tea. As a next step, QST was performed on the non-dominant hand to determine the effect of TSD on nociception duration: 30 min. Upon completion of QST, a cold pressor test was performed see below.

A detailed description on testing procedures and quantitative assessment has been formerly published Schuh-Hofer et al. The following description is restricted to the assessment of nociceptive thresholds, since the presented study only relates to these parameters. For measuring MPTs of pricking forces, pinprick devices with a flat contact area of 0. Pinprick devices were applied in five series of ascending and descending stimulus intensities.

MPT was then determined by calculating the geometric mean of the 5 series of ascending and descending stimulus intensities. The arithmetical mean of three measurements was then calculated to determine the PPT. Subjects were instructed to pull their hand out of the water as soon as the painful sensation became intolerable with a predetermined maximum exposition time of s.

After completion of the study, plasma samples were sent on dry ice to Munich, Germany. The assay detection limit was 0. Saliva was collected by using cortisol salivettes with a synthetic swab Reg. Saliva samples were centrifuged at g for 10 min.

Cortisol levels were determined employing a competitive solid phase time-resolved fluorescence immunoassay with flouromeric end point detection DELFIA. Standards, controls saliva pools and samples were given in duplicate wells. The intra-assay coefficient of variation was between 4. For direct comparison of outcome parameters under the two conditions HS and TSD, paired t -tests were additionally performed.

To determine the overall relation between OT levels and the respective outcome parameters, linear regression analyses were performed. All data passed tests for normality Normality test Shapiro—Wilk and homogeneity of variance.

Effect of sleep deprivation on plasma oxytocin and cortisol. A We found a significant effect of TSD on oxytocin levels in females left , but not males right.

The mandatory prerequisite of our study was to induce pain hypersensitivity and increased state anxiety levels by TSD. Table 3 shows that the effect sizes related to this study population are similar to those of our previously published larger study group, of which our study participants represent a subgroup [see Eichhorn et al.

Like previously shown Eichhorn et al. Effect of sleep deprivation on nociceptive thresholds. The figures depict raw data of quantitative sensory testing, based on the mixed gender population. With respect to mechanical submodalities, the sensitivity to pricking stimuli MPT , but not to blunt pressure PPT , was significantly increased. Effect of sleep deprivation on descending pain inhibition.

B Consequently, the effect of TSD on the entire study population was not significant. Figure 4 depicts results both separated by sex and based on the mixed gender population. Effect of sleep deprivation on anxiety levels. A The significant effect of TSD on State Anxiety was prominent in both females and males, and consequently in the entire study population B. Solid line brackets are related to paired t -tests. However, based on the entire study population, we found a significant correlation between plasma OT-levels and HPTs.

Correlation between OT and descending pain inhibition. Values below the dashed line indicate pain inhibition while values above the line indicate pain facilitation due to ice cold water exposition.

Based on the sex-mixed population, results were not significant C. Correlation between OT-levels and state anxiety. Hierarchical Regression Model: correlation between salivary cortisol and oxytocin.

To our knowledge, human studies on the contribution of OT to the pathophysiology of sleep disruption are lacking so far. Only two rodent studies have been published on this topic.

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Karl schlaepfer erectile dysfunction

Karl schlaepfer erectile dysfunction

Karl schlaepfer erectile dysfunction

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Population dynamics of roundjaw bonefish Albula glossodonta at a remote coralline Atoll inform community-based management in an artisanal fishery.

Fisheries Management and Ecology Length-based assessment of an artisanal Albulid fishery in the South Pacific: A data-limited approach for management and conservation. Marine and Coastal Fisheries Litt, M. Etherington, L. Gutowsky, N. Lapointe, and S. In Press. Does catch-and-release angling pose a threat to American Eel? A hooking mortality experiment. Endangered Species Research. Sopinka, N. Coristine, M. De Rosa, C. Rochman, B. Owens and S. Envisioning the scientific paper of the future.

Walton-Rabideau, S. Lawrence River nursery bays their inaugural fall and winter. Ecology of Freshwater Fish. Cooke, S. Bennett and H. In Press Physiological consequences of varying shark exposure on a large teleost species. Canadian Journal of Zoology A practical method to account for variation in detection range in acoustic telemetry arrays to accurately quantify the spatial ecology of aquatic animals.

Methods in Ecology and Evolution. Hayden, T. In press. Telemetry reveals limited exchange of walleye between Lake Erie and Lake Huron: movement of two populations through the Huron-Erie corridor. Journal of Great Lakes Research.

Reid, A. Carlson, D. Hanna, J. Olden, S. Ormerod, S. Conservation challenges to freshwater ecosystems. Chapter X in S. Elias, editor. Pleizier, N. Nelson, S. Cooke and C. Understanding gas bubble trauma in an era of hydropower expansion: How do fish compensate at depth?

Canadian Journal of Fisheries and Aquatic Sciences. Bao, J. Li, C. Zhang, X. Mi, H. Li, X. Zhao, N. Cao, W. Twardek, S. Cooke and M.

Quantitative assessment of fish passage efficiency at a vertical-slot fishway on the Daduhe River in Southwest China. Ecological Engineering. Flecker, A. Twining, O. Schmitz, S. Cooke and N. Aquatic predators influence micronutrients: Important but understudied. Trends in Ecology and Evolution. Revealing migration and reproductive habitat of invasive fish under an active population suppression program. Conservation Science and Practice. Soroye, A. Kadykalo, T.

Ward, E. Paquette, A. Abrams, D. Algera, D. Demers, L. Epp, M. Giles, M. Litt, B. Manouchehri, R. James, S. McBeth, A. Paradis, L. Pittet, J. Sebes, S. Steell, A. Thompson, P. Tremblay, E. Tuononen, J. Kerr, J. Bennett and S.

Environmental Reviews. Lawrence, G. Raby, A. Teffer, K. Jeffries, A. Danylchuk and T. Comment on Duman et al. North American Journal of Aquaculture.

Reid, C. Vandergoot, J. Midwood, E. Stevens, J. Bowker and S. On the electroimmobilization of fishes for research and practice: opportunities, challenges, and research needs.

Karl schlaepfer erectile dysfunction